6 Years of Research on the Microbiome Offers A New Perspective on Skin Health

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For decades, the focus in skin research has been on the physical barrier.  New research now unveils a diverse community of micro-organisms that live on the skin barrier – THE MICROBIOME. Both the physical barrier and the microbiome have their own functions and how they interact with each other is just being discovered. This new research has demonstrated that for healthy skin, it is not enough to maintain the natural protective barrier alone. In fact it is also important to consider the microbiome, skin’s “invisible barrier.” A pioneer in advancing dermatology, La Roche- Posay has dedicated 6 years of research and conducted more than 10 clinical studies to gain a new understanding on the microbiome, its inter-correlation with the physical barrier and what it could mean for the future of skincare. The brand’s key findings in this new field have been presented at major congresses of dermatology around the world – including the World Congress of Dermatology in Vancouver in 2015 – and have been published in influential journals of dermatology.

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Skin’s microbiome is comprised of over 100 billion bacteria, fungi and viruses that populate the skin, interact with each other and with skin barrier. New understanding of these micro-organisms show that there is no such thing as good and bad bacteria but rather that bacterial diversity is needed for a healthy microbiome. Indeed, we now know that alterations of the microbiome are often associated with a disrupted skin barrier – this can happen when one or more species overpopulates, taking the space of other bacteria*.

Research is showing a connection between the health of your microbiome and the overall health of skin. It’s important for us, as dermatologists, to understand the influence it has on skin – inside and out – so we can make the best recommendations when treating patients.” says Dr. Hilary Baldwin. “It’s a fascinating subject we’re learning more about every day.”

Through research, we are able to understand that prebiotics are beneficial for bacteria as they work by creating an environment that is able to support a good diverse skin microbiome.



Stemming from 6 years of research in dermatology and more than 10 clinical studies


With this new research in mind, La Roche-Posay is proud to introduce TOLERIANE Double Repair Moisturizer: a new generation of daily skincare. Formulated with carefully selected ingredients, TOLERIANE Double Repair Moisturizer works in two ways to replenish long-lasting moisture and help restore the skin barrier. TOLERIANE Double Repair Moisturizer replenishes moisture for up to 48-hour hydration** and helps restore skin’s natural protective barrier after 1 hour***. TOLERIANE Double Repair Moisturizer has been developed under a stringent formulation charter, excluding oils, fragrance and parabens and has been dermatologist-tested to be safe on sensitive skin.


  • Immediately restores the feeling of skin comfort
  • Significant barrier recovery after 1 hour after simulated barrier disruption by tape stripping
  • Up to 48 hours of hydration
  • Restores skin’s essential lipids, and helps restore skin’s natural protective barrier
  • Dermatologist tested to be safe for sensitive skin
  • Allergy tested
  • Non comedogenic / Oil-free
  • Fragrance-free

TOLERIANE Double Repair Moisturizer is part of a full line of products, including an SPF version and two complementary cleansers:

  • TOLERIANE Purifying Foaming Cleanser (400ml – 13.5 fl.oz):

For normal to oily skin. Effectively cleanses and removes excess oil.

  • TOLERIANE Hydrating Gentle Cleanser (400ml – 13.5 fl.oz):

For normal to dry skin. Gently cleanses while retaining essential moisture.

  • Toleriane Double Repair Moisturizer (75ml – 2.5 fl.oz):

Provides up to 48hr hydration.

  • Toleriane Double Repair Moisturizer UV – Broad Spectrum SPF30 (75ml – 2.5 fl.oz):

Helps protect and provides all day hydration.


  • Ceramide-3: an essential ceramide naturally found in skin.
  • La Roche-Posay Prebiotic Thermal Water: with hydrating, soothing, and antioxidant properties.
  • Niacinamide: A form of vitamin B3 with soothing properties.
  • Glycerin: a moisturizing agent that naturally attracts water to skin.

La Roche-Posay TOLERIANE Moisturizers have a suggested retail price of $19.99

TOLERIANE Cleansers have a suggested retail price of $14.99.

They can be purchased at CVS/pharmacy, Walgreens, Target, Ulta, Duane Reade, select physicians’ offices and online at

* The NIH HMP Working Group et al. Genome Res. 2009;19:2317-2323

**Corneometer measurements on 24 women ages 18-65 years old

***TEWL measurements after tape stripping on 25 women ages 22-65 years old


Recommended by  more  than  25,000 dermatologists worldwide,  La  Roche-Posay offers  a  unique  range  of  daily  skincare developed with dermatologists for every skin type to complement and enhance their patients’ treatments and to promote good skincare practices at home every day. Started from Europe’s leading center of thermal dermatology, La Roche-Posay develops formulas with its exclusive Selenium-rich water, used at the center since 1905, due to its antioxidant and soothing properties. The products are developed using a strict formulation charter with a minimal number of ingredients and are formulated with ingredients at optimal concentrations. Additionally, La Roche-Posay products undergo stringent clinical testing for efficacy and safety, even on sensitive skin.

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